Article
Thymidine kinase as a selectable marker for studying the biogenesis of glycosomes in Trypanosoma brucei.
Experimental parasitology - 1 Mar 1996
Lye L, Wang C C
Abstract excerpt
The import of proteins into the glycosome of T. brucei has been studied as a potential target for antitrypanosomal chemotherapy. We have previously reported on the C-terminal tripeptides, such as SKL and its analogs, which function as targeting signals in the import of proteins into glycosomes. Recently, we tested the herpes simplex virus thymidine kinase gene (tk) as both a potential positive and a negative...
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