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Article

The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei.

Nucleic acids research - 15 May 1996

Valdés J, Taylor M C, Cross M A, Ligtenberg M J, Rudenko G, Borst P

Abstract excerpt

We have tested the use of thymidine kinase as a negative selection system for Trypanosoma brucei. To this end we have targeted a construct containing a Herpes simplex virus thymidine kinase (TK) gene into the ribosomal DNA array of procyclic T. brucei. This resulted in TK activity 30-50-fold above background and in susceptibility to the nucleoside analogues ganciclovir, ethyl-deoxyuridine and...

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Identifiers

PMID: 8657559
DOI: 10.1093/nar/24.10.1809
PMCID: PMC145877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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