Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of a bloodstream form Trypanosoma brucei double glycosyltransferase null mutant competent in receptor-mediated endocytosis of transferrin.

PLoS pathogens - 1 Jun 2024

Duncan Samuel M, Carbajo Carla Gilabert, Nagar Rupa, Zhong Qi, Breen Conor, Ferguson Michael A J, Tiengwe Calvin

Abstract excerpt

The bloodstream form of Trypanosoma brucei expresses large poly-N-acetyllactosamine (pNAL) chains on complex N-glycans of a subset of glycoproteins. It has been hypothesised that pNAL may be required for receptor-mediated endocytosis. African trypanosomes contain a unique family of glycosyltransferases, the GT67 family. Two of these, TbGT10 and TbGT8, have been shown to be involved in pNAL biosynthesis in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocytosis
Share to Glycosyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polysaccharides

Share to Protozoan Proteins

Share to Receptors, Transferrin

Share to Transferrin

Share to Trypanosoma brucei brucei

Share to Trypanosomiasis, African

Source

Open in PubMed Open full text

Identifiers

PMID: 38935804
DOI: 10.1371/journal.ppat.1012333
PMCID: PMC11236118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of a bloodstream form Trypanosoma brucei double glycosyltransferase null mutant competent in receptor-mediated endocytosis of transferrin.PMID 38935804Read ↗

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei.Semantic proximity Read ↗

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.Semantic proximity Read ↗

Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi ParasitesSemantic proximity Read ↗

Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei.Semantic proximity Read ↗

Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant.Semantic proximity Read ↗

Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1.Semantic proximity Read ↗

The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases.Semantic proximity Read ↗

Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.Semantic proximity Read ↗

Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferasesSemantic proximity Read ↗

Deletion of the glucosidase II gene in Trypanosoma brucei reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein.Semantic proximity Read ↗

Generation of constitutive and inducible trans-sialylation dominant-negative phenotypes in Trypanosoma brucei and Trypanosoma cruzi.Semantic proximity Read ↗

PSSA-2, a membrane-spanning phosphoprotein of Trypanosoma brucei, is required for efficient maturation of infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.