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In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or -2.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2006

Finan Katherine M, Hodge Greg, Reynolds Ann M, Hodge Sandra, Holmes Mark D, Baker Andrew H, Reynolds Paul N

Abstract excerpt

Matrix metalloproteinases (MMPs) are essential for extracellular matrix (ECM) breakdown and repair, and have been implicated in the development of metastases. TIMP-3 was initially identified as a potent inhibitor of MMPs, however it also has several properties that are unique and not related to its ability to abrogate MMPs. We studied the effects of overexpression of tissue inhibitor of metalloproteinases-3...

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Identifiers

PMID: 16860902
DOI: 10.1016/j.lungcan.2006.06.006

Genes

TIMP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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