Oncogenic consequences of down-modulating TIMP expression in 3T3 cells with antisense RNA.

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Article

Oncogenic consequences of down-modulating TIMP expression in 3T3 cells with antisense RNA.

Matrix (Stuttgart, Germany). Supplement - 1 Jan 1992

Denhardt D T, Khokha R, Yagel S, Overall C M, Parhar R S

Abstract excerpt

We have used recombinant DNA technology to engineer a set of murine 3T3 cell lines that vary in the extent to which they express TIMP, tissue inhibitor of metalloproteinases, and we have found that both invasiveness and tumorigenic potential are conferred when TIMP production is impaired. These cell clones were produced by transfecting immortal Swiss 3T3 cells with plasmid constructs capable of expressing...

Topics

3T3 Cells
Animals
Basement Membrane
Cell Line, Transformed
Cell Transformation, Neoplastic
Gene Expression Regulation
Genes, Tumor Suppressor
Glycoproteins
Mice
Mice, Nude
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Phenotype

RNA, Antisense

Recombinant Fusion Proteins

Tissue Inhibitor of Metalloproteinases

Transfection

Source

Open in PubMed

Identifiers

PMID: 1480038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1480038-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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