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Article

Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo.

Journal of experimental therapeutics & oncology - 1 Jan 2006

Sanders Andrew J, Parr Christian, Davies Gaynor, Martin Tracey A, Lane Jane, Mason Malcolm D, Jiang Wen G

Abstract excerpt

PURPOSE: Matriptase-1 has been implicated as playing an important role in various types of cancer progression through many different cancer related pathways. In the current study we assessed the efficacy of targeting matriptase-1 using ribozyme technology in vitro and in vivo. EXPERIMENTAL DESIGN: Matriptase-1 expression was reduced in the PC-3 and DU-145 cell line using hammerhead ribozyme transgenes. In vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17228523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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