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Article

Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection.

Journal of virology - 1 Nov 2010

Zornetzer Gregory A, Frieman Matthew B, Rosenzweig Elizabeth, Korth Marcus J, Page Carly, Baric Ralph S, Katze Michael G

Abstract excerpt

Severe acute respiratory syndrome coronavirus (SARS-CoV) infection can cause the development of severe end-stage lung disease characterized by acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. The mechanisms by which pulmonary lesions and fibrosis are generated during SARS-CoV infection are not known. Using high-throughput mRNA profiling, we examined the transcriptional response of wild-type...

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Source

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Identifiers

PMID: 20702617
DOI: 10.1128/JVI.01130-10
PMCID: PMC2953159

Genes

STAT1
IFNAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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