Article
Generation of mice with a conditional Stat1 null allele.
Transgenic research - 1 Feb 2012
Wallner Barbara, Leitner Nicole R, Vielnascher Raimund M, Kernbauer Elisabeth, Kolbe Thomas, Karaghiosoff Marina, Rülicke Thomas, Decker Thomas, Müller Mathias
Abstract excerpt
Interferons (IFNs) are key cytokines in the innate immune response that also bridge the gap to adaptive immunity. Signaling upon stimulation by IFN type I, II and III is mediated by the Jak-Stat pathway. STAT1 is activated by all three IFN receptor complexes and absence of STAT1 from mice increases their susceptibility to pathogens. In addition, depending on the setting, STAT1 can act as tumor suppressor or...
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