Article
Instability of long inverted repeats within mouse transgenes.
The EMBO journal - 1 Mar 1996
Collick A, Drew J, Penberth J, Bois P, Luckett J, Scaerou F, Jeffreys A, Reik W
Abstract excerpt
Various sequences in the mammalian genomes are unstable. One class of sequence arrangement is long inverted repeats, which are known to be unstable in bacteria and yeast. While in mammals some evidence suggests that short inverted repeats (<10 bp long) may show instability, nothing is known about the stability of long inverted repeats. Here we describe two unrelated multicopy transgenes in the mouse (loci 109 and...
Topics
- Animals
- Base Sequence
- DNA
- DNA Primers
- Female
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Mice, Transgenic
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Polymerase Chain Reaction
- Rats
- Repetitive Sequences, Nucleic Acid
- Sequence Deletion