Article

Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis

2017-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Transgenesis has been a mainstay of mouse genetics for over 30 years, providing numerous models of human disease and critical genetic tools in widespread use today. Generated through the random integration of DNA fragments into the host genome, transgenesis can lead to insertional mutagenesis if a coding gene or essential element is disrupted, and there is evidence that larger scale structural v...

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Literature Corpus work: c59af181-eea7-50c5-a3ae-d6ebe0a6f921
DOI: 10.1101/236307

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