Palindromic DNA and genome stability. Further studies.

Abstract excerpt

Unusual DNA structures promote genetic instability. One such example is hairpin DNA, which can form from palindromic sequences and triplet repeats, and is also a characteristic intermediate in V(D)J recombination. We previously found that a large 15.3-kb palindrome that was introduced as a transgene into the mouse germline was highly unstable. Although it could be transmitted, the transgene was found to be...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosome Inversion
• Share to Mice, Inbred CBA
• Share to Mice, Transgenic