Increased rate of transcription contributes to elevated expression of the mutant p53 gene in Burkitt's lymphoma cells.

Abstract excerpt

Mutations and elevated levels of the p53 tumor suppressor protein have been reported in Burkitt's lymphomas (BL). We investigated whether elevated levels of the mutant p53 protein can be due to transcriptional or posttranscriptional mechanisms. In surveying a series of B-lymphoid cell lines, we found that a high level of the p53 protein tended to reflect high steady-state levels of p53 mRNA. p53 mRNA exhibited...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Burkitt Lymphoma
• Share to Genes, p53
• Share to Mutation