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Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication

15 Feb 2010

Abstract excerpt

Expression of Epstein-Barr Virus BZLF1, a key protein initiating the switch from latent to lytic infection, is known to cause cell growth arrest by accumulating p53 and p21(WAF1/CIP1) in epithelial cells, but its molecular mechanism remains elusive. We found here that the BZLF1 protein stimulates p53 binding to its recognition sequence. The BZLF1 accelerated the rate of p53-DNA complex formation through the...

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PMID: 20139729
DOI: 10.4161/cc.9.4.10675

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