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Article

Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

Science (New York, N.Y.) - 19 Apr 1996

Gong S, Nussenzweig M C

Abstract excerpt

Many of the cell fate decisions in precursor B cells and more mature B cells are controlled by membrane immunoglobulin (Ig)M heavy chain (mu) and the Ig alpha-Ig beta signal transducers. The role of Ig beta in regulating early B cell development was examined in mice that lack Ig beta (Ig beta-/-). These mice had a complete block in B cell development at the immature CD43+B220+ stage. Immunoglobulin heavy chain...

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Identifiers

PMID: 8602530
DOI: 10.1126/science.272.5260.411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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