Article
Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.
Science (New York, N.Y.) - 19 Apr 1996
Gong S, Nussenzweig M C
Abstract excerpt
Many of the cell fate decisions in precursor B cells and more mature B cells are controlled by membrane immunoglobulin (Ig)M heavy chain (mu) and the Ig alpha-Ig beta signal transducers. The role of Ig beta in regulating early B cell development was examined in mice that lack Ig beta (Ig beta-/-)...
Topics
- Animals
- Antigens, CD
- B-Lymphocytes
- CD79 Antigens
- Gene Expression
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Targeting
- Genes, Immunoglobulin
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Immunoglobulin mu-Chains
- Lymph Nodes
- Mice
- Mice, Inbred C57BL
- Mutation
- RNA, Messenger