Article
Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire.
Journal of molecular biology - 22 Jan 1999
de Wildt R M, Hoet R M, van Venrooij W J, Tomlinson I M, Winter G
Abstract excerpt
In the bone marrow, diversity in the primary antibody repertoire is created by the combinatorial rearrangement of different gene segments and by the association of different heavy and light chains. During the secondary response in the germinal centres, antibodies are diversified by somatic mutati...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Clone Cells
- Female
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Male
- Molecular Sequence Data
- Mutation
- Receptors, IgG