Article
Parasites and individual major histocompatibility complex diversity--an optimal choice?
Microbes and infection - 1 Oct 2004
Wegner K Mathias, Kalbe Martin, Schaschl Helmut, Reusch Thorsten B H
Abstract excerpt
Overdominant selection or heterozygote advantage can partly explain the extraordinary polymorphism found at classical major histocompatibility complex (MHC) loci. However, several studies employing only single infectious agents often failed to detect it. Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in...
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