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Article

Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells.

Journal of neuroscience research - 1 Feb 1997

Zhao B, Chrest F J, Horton W E, Sisodia S S, Kusiak J W

Abstract excerpt

The cause of neuronal loss in Alzheimer disease is unknown. We investigated the effects on survival of PC12 cells expressing A692G, E693Q, and V717F mutant amyloid precursor proteins (APP). Differentiated cells expressing mutant APPs exhibited somal shrinkage, followed by cell detachment from the...

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PMID: 9039647

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9039647-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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