Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Death and survival of neuronal cells exposed to Alzheimer's insults.

Journal of neuroscience research - 1 Nov 2002

Niikura Takako, Hashimoto Yuichi, Tajima Hirohisa, Nishimoto Ikuo

Abstract excerpt

Neuronal cell death is the central abnormality occurring in brains suffering from Alzheimer's disease (AD). The notion that AD is a disease caused by loss of neurons points toward suppression of neuronal death as the most important therapeutic target. Nevertheless, the mechanisms for neuronal death in AD are still relatively unclear. Three known mutant genes cause familial AD (FAD): amyloid precursor protein,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Death

Share to Intracellular Signaling Peptides and Proteins

Share to Neurons

Share to Presenilin-1

Share to Proteins

Source

Identifiers

PMID: 12391601
DOI: 10.1002/jnr.10354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Death and survival of neuronal cells exposed to Alzheimer's insults.PMID 12391601Read ↗

Mechanisms of Neuronal Death in Alzheimer's DiseaseSemantic proximity Read ↗

Are Abeta and its derivatives causative agents or innocent bystanders in AD?Semantic proximity Read ↗

Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons.Semantic proximity Read ↗

Caspases, Apoptosis, and Alzheimer Disease: Causation, Correlation, and ConfusionSemantic proximity Read ↗

Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.Semantic proximity Read ↗

Targeting Alzheimer's disease with gene and cell therapiesSemantic proximity Read ↗

Apoptosis in the nervous system.Semantic proximity Read ↗

Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.Semantic proximity Read ↗

Increased apoptotic cell death in sporadic and genetic Alzheimer's disease.Semantic proximity Read ↗

Cell death mechanisms in neurodegenerationSemantic proximity Read ↗

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.Semantic proximity Read ↗

Apoptosis and in vitro Alzheimer’s disease neuronal modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.