Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons.

Journal of neuroscience research - 1 Jul 2004

Niikura Takako, Yamada Marina, Chiba Tomohiro, Aiso Sadakazu, Matsuoka Masaaki, Nishimoto Ikuo

Abstract excerpt

Amyloid precursor protein (AbetaPP), a precursor of amyloid beta (Abeta) peptide, is one of the molecules involved in the pathogenesis of Alzheimer's disease (AD). Specific mutations in AbetaPP have been found in patients inheriting familial AD (FAD). These mutant AbetaPP proteins cause cell death in neuronal cell lines in vitro, but the molecular mechanism of cytotoxicity has not yet been clarified completely....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase Inhibitors
Share to GTP-Binding Protein alpha Subunits, Gi-Go

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to JNK Mitogen-Activated Protein Kinases

Share to Mice, Inbred ICR

Share to NADPH Oxidases

Share to Neuroprotective Agents

Share to Neurotoxins

Share to p38 Mitogen-Activated Protein Kinases

Source

Identifiers

PMID: 15197738
DOI: 10.1002/jnr.20139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons.PMID 15197738Read ↗

Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.Semantic proximity Read ↗

Death and survival of neuronal cells exposed to Alzheimer's insults.Semantic proximity Read ↗

Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.Semantic proximity Read ↗

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.Semantic proximity Read ↗

Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.Semantic proximity Read ↗

Identification of a mutant amyloid peptide that predominantly forms neurotoxic protofibrillar aggregates.Semantic proximity Read ↗

A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality.Semantic proximity Read ↗

Mutant Superoxide Dismutase-1-Linked Familial Amyotrophic Lateral Sclerosis: Molecular Mechanisms of Neuronal Death and ProtectionSemantic proximity Read ↗

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.Semantic proximity Read ↗

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.Semantic proximity Read ↗

Differential Induction of Immediate Early Gene Proteins in Cultured Neurons by β‐Amyloid (Aβ): Association of c‐Jun with Aβ‐Induced ApoptosisSemantic proximity Read ↗

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.