Article
Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.
Journal of neuroscience research - 15 Apr 2001
Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Müller W E
Abstract excerpt
The Swedish double mutation (KM670/671NL) of amyloid precursor protein (APPsw) is associated with early-onset familial Alzheimer's disease (FAD) and results in from three- to sixfold increased beta-amyloid production. The goal of the present study was to elucidate the effects of APPsw on mechanisms of apoptotic cell death. Therefore, PC12 cells were stably transfected with human APPsw. Here we report that the...
Topics
- Alzheimer Disease
- Amino Acid Chloromethyl Ketones
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Anilides
- Animals
- Antioxidants
- Apoptosis
- Aspartic Acid Endopeptidases
- Caspase 3
- Caspases
- Cysteine Proteinase Inhibitors
- Endopeptidases