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Article

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jul 2003

McPhie Donna L, Coopersmith Robert, Hines-Peralta Andrew, Chen Yuzhi, Ivins Kathryn J, Manly Susan P, Kozlowski Michael R, Neve Kim A, Neve Rachael L

Abstract excerpt

Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals with Alzheimer disease (AD). However, the signaling mechanisms that mediate these events have not been defined. We show that expression of familial AD (FAD) mutants of the amyloid precursor protein (APP) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12890786
PMCID: PMC6740729

Genes

APP
PAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12890786-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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