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Article

Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.

Journal of neuroscience research - 15 Aug 2004

Abe Yoichiro, Hashimoto Yuichi, Tomita Yusuke, Terashita Kenzo, Aiso Sadakazu, Tajima Hirohisa, Niikura Takako, Matsuoka Masaaki, Nishimoto Ikuo

Abstract excerpt

Although neurotoxic functions are well characterized in familial Alzheimer's disease (FAD)-linked N141I mutant of presenilin (PS)2, little has been known about M239V-PS2, another established FAD-causative mutant. We found that expression of M239V-PS2 caused neuronal cytotoxicity. M239V-PS2 exerted three forms of cytotoxicity: one was sensitive to both an antioxidant glutathione-ethyl-ester (GEE) and a caspase...

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Identifiers

PMID: 15264228
DOI: 10.1002/jnr.20163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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