Article
Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway.
The Journal of biological chemistry - 25 Jul 2003
Marques Celio A, Keil Uta, Bonert Astrid, Steiner Barbara, Haass Christian, Muller Walter E, Eckert Anne
Abstract excerpt
Autosomal dominant forms of familial Alzheimer's disease (FAD) are caused by mutations of the amyloid precursor protein (APP) gene and by mutations of the genes encoding for presenilin 1 or presenilin 2. Simultaneously, evidence is provided that increased oxidative stress might play a crucial role in the rapid progression of the Swedish FAD. Here we investigated the effect of the Swedish double mutation...
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