Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.

3 Jul 1995

Abstract excerpt

The human VHL tumor suppressor gene has been implicated in the inherited disorder von Hippel-Lindau disease and in sporadic renal carcinoma. The homologous rat gene encodes a 185-amino acid protein that is 88% sequence identical to the aligned 213-amino acid human VHL gene product. When expressed in COS-7 cells, both the human and the rat VHL proteins showed predominant nuclear, nuclear and cytosolic, or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7604013
DOI: 10.1073/pnas.92.14.6459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.PMID 7604013Read ↗

VHL down-regulation and differential localization as mechanisms in tumorigenesis.Semantic proximity Read ↗

Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region.Semantic proximity Read ↗

Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis.Semantic proximity Read ↗

Novel human pathological mutations. Gene symbol: VHL. Disease: Von Hippel-Lindau syndrome.Semantic proximity Read ↗

Von Hippel-Lindau disease and sporadic renal cell carcinoma.Semantic proximity Read ↗

VHL protein alterations in sporadic renal cell carcinoma.Semantic proximity Read ↗

The von Hippel-Lindau gene and protein in tumorigenesis and angiogenesis: a potential target for therapeutic designs.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor gene. A rare and intriguing disease opening new insight into basic mechanisms of carcinogenesis.Semantic proximity Read ↗

Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.Semantic proximity Read ↗

Role of VHL gene mutation in human renal cell carcinoma.Semantic proximity Read ↗

Rescuing the Function of Missense-Mutated Tumor Suppressor <i>VHL</i> using Stabilizing Small MoleculesSemantic proximity Read ↗

Mutations of the VHL tumour suppressor gene in renal carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.