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Article

Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis.

Seminars in oncology - 1 Feb 1995

Gnarra J R, Lerman M I, Zbar B, Linehan W M

Abstract excerpt

Using a genetic linkage-based positional cloning approach the VHL gene was identified at chromosome 3p25.5. VHL is mutated in the germlines of affected individuals, and in VHL-associated tumors the mutation is almost always exposed by virtue of chromosomal deletion of the inherited wild-type alle...

Topics

Carcinoma, Renal Cell
Chromosome Deletion
Chromosomes, Human, Pair 3
DNA, Complementary
Genetic Linkage
Humans
Kidney Neoplasms
Mutation
von Hippel-Lindau Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7855617

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7855617-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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