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Article

RRP22 Is a Farnesylated, Nucleolar, Ras-Related Protein with Tumor Suppressor Potential

15 Apr 2005

Abstract excerpt

Ras proteins are members of a superfamily of related small GTPases. Some members, such as Ras, are oncogenic. However, other members seem to serve as tumor suppressors, such as Rig and Noey2. We now identify and characterize a novel member of the Ras superfamily, RRP22. Like Ras, RRP22 can be posttranslationally modified by farnesyl. Unlike Ras, RRP22 inhibits cell growth and promotes caspase-independent cell...

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PMID: 15833841
DOI: 10.1158/0008-5472.can-04-0749

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Source receipt: pubmed, retrieved 7 Sept 2026.

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