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Article

MRP8/ABCC11 directly confers resistance to 5-fluorouracil

1 Jan 2007

Abstract excerpt

Multidrug-resistance-associated protein, MRP8/ABCC11 (ABCC11), is an efflux pump for nucleotide analogues and 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP). To test whether ABCC11 directly confers 5-fluorouracil (5-FU) resistance, we used the 5-FU-resistant subline PC-6/FU23-26 selected from PC-6 human small-cell lung cancer cells by 5-FU and found that it increases the resistance by approximately 25-fold....

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PMID: 17237272
DOI: 10.1158/1535-7163.mct-06-0529

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