Article
Genetic mechanisms of drug resistance. A review.
Acta oncologica (Stockholm, Sweden) - 1 Jan 1991
Borst P
Abstract excerpt
An overview of our present understanding of mechanisms of resistance against cytotoxic drugs is presented. Most of this understanding has come from studies on tumor cells made resistant in vitro, but there is reason to think that similar mechanisms are responsible for resistance in patients. After a brief overview of biochemical mechanisms of drug resistance, the types of mutations in tumor cells that can alter...
Topics
- Alkylating Agents
- Antineoplastic Agents
- Drug Resistance
- Humans
- Membrane Proteins
- Methotrexate
- Mutation
- Neoplasms