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Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells

8 Jan 2024

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered. In this study, an MTX-resistant cell line (Reh-MTXR) was established through a stepwise selection process from the ALL cell line Reh. Comparative analysis revealed that Reh-MTXR cells...

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PMID: 38259297
DOI: 10.3389/fphar.2023.1331687

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