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Article

The mycobacterial LysR-type regulator OxyS responds to oxidative stress and negatively regulates expression of the catalase-peroxidase gene.

PloS one - 1 Jan 2012

Li Yuqing, He Zheng-Guo

Abstract excerpt

Protection against oxidative stress is one of the primary defense mechanisms contributing to the survival of Mycobacterium tuberculosis in the host. In this study, we provide evidence that OxyS, a LysR-type transcriptional regulator functions as an oxidative stress response regulator in mycobacteria. Overexpression of OxyS lowers expression of the catalase-peroxidase (KatG) gene in M. smegmatis. OxyS binds...

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Identifiers

PMID: 22272299
DOI: 10.1371/journal.pone.0030186
PMCID: PMC3260234

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