Article
Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred.
Journal of medical genetics - 1 Nov 1995
Newport M, Levin M, Blackwell J, Shaw M A, Williamson R, Huxley C
Abstract excerpt
In mice, susceptibility to intracellular infections in inbred strains is controlled by a single locus, Lsh/Ity/Bcg, and the gene responsible has been cloned and designated Nramp (Natural resistance associated macrophage protein). We have identified a group of related children who appear to have a...
Topics
- Animals
- Base Sequence
- Carrier Proteins
- Cation Transport Proteins
- Child
- Chromosomes, Human, Pair 2
- Disease Susceptibility
- Female
- Genes, Recessive
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Immunologic Deficiency Syndromes
- Iron-Binding Proteins
- Macrophage Activation