Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred.

Journal of medical genetics - 1 Nov 1995

Newport M, Levin M, Blackwell J, Shaw M A, Williamson R, Huxley C

Abstract excerpt

In mice, susceptibility to intracellular infections in inbred strains is controlled by a single locus, Lsh/Ity/Bcg, and the gene responsible has been cloned and designated Nramp (Natural resistance associated macrophage protein). We have identified a group of related children who appear to have a single gene defect, inherited recessively, which results in increased susceptibility to myocabacterial infection. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Genes, Recessive

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to Membrane Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8592339
DOI: 10.1136/jmg.32.11.904
PMCID: PMC1051747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred.PMID 8592339Read ↗

Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).Semantic proximity Read ↗

Susceptibility to leprosy is linked to the human NRAMP1 gene.Semantic proximity Read ↗

Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.Semantic proximity Read ↗

The Nramp1 protein and its role in resistance to infection and macrophage function.Semantic proximity Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.Semantic proximity Read ↗

The Bcg host-resistance gene.Semantic proximity Read ↗

Susceptibility to mycobacterial infections: the importance of host genetics.Semantic proximity Read ↗

Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans.Semantic proximity Read ↗

Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism.Semantic proximity Read ↗

Genetic lessons learned from X-linked Mendelian susceptibility to mycobacterial diseases.Semantic proximity Read ↗

Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.