Simulating the process of malignant transformation.

doi:10.1016/0025-5564(94)90008-6

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Article

Simulating the process of malignant transformation.

Mathematical biosciences - 1 Oct 1994

Luebeck E G, Moolgavkar S H

Abstract excerpt

A computationally efficient method for the simulation of carcinogenesis is presented. The underlying model for the process is the two-mutation clonal expansion model with explicit consideration of stochastic growth of malignant tumors. The usual likelihood-based methods of analysis ignore the gro...

Topics

Animals
Cell Transformation, Neoplastic
Humans
Likelihood Functions
Mathematics
Models, Biological
Mutation
Neoplasms
Neoplastic Stem Cells

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