Are two mutations sufficient to cause cancer? Some generalizations of the two-mutation model of carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the multistage model of Armitage and Doll.

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Article

Are two mutations sufficient to cause cancer? Some generalizations of the two-mutation model of carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the multistage model of Armitage and Doll.

Biometrics - 1 Dec 1995

Little M P

Abstract excerpt

Some generalizations of the two-mutation carcinogenesis model of Moolgavkar, Venzon, and Knudson (to allow for an arbitrary number of mutational stages) and of the multistage model of Armitage and Doll are shown to have the property that, at least in the case when the parameters of the model are eventually constant, the excess relative and absolute risks following changes in any of the parameters will eventually...

Topics

Biometry
Cocarcinogenesis
Female
Humans
Models, Genetic
Mutation
Neoplasms
Neoplasms, Radiation-Induced
Nuclear Warfare
Proportional Hazards Models
Uterine Cervical Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8589222

Provenance

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