Article
A mutational model of carcinogenesis.
Anticancer research - 1 Jan 2000
Morris J A
Abstract excerpt
A model of carcinogenesis based on spontaneous somatic mutation in expanding cell clones is presented and compared with previous mathematical treatments of this concept. The model shows that if cancer is purely a consequence of gene mutation then four independent mutations are required. To explai...
Topics
- Age Factors
- Carcinogens
- Cell Division
- Humans
- Models, Biological
- Models, Theoretical
- Mutagenesis
- Mutation
- Neoplasms
- Probability