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Article

A 4-mutation model of carcinogenesis for tumour suppressor genes.

Anticancer research - 1 Jan 2000

Den Otter W, Koten J W

Abstract excerpt

Human life can be described as the clonal development of a fertilized egg. During cell proliferation in this clone among others cancer-specific mutations arise. Supposing that about 10(16) cells are produced in a lifetime; that the mutation frequency is about 10(-6) per gene per cell generation; that cells can go through about 60 cell divisions; and that cancer arises about once in a lifetime, carcinogenesis is...

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PMID: 10697598

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