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Article

Multistage carcinogenesis and the incidence of human cancer

8 Oct 2003

Abstract excerpt

We consider the implications of multistage carcinogenesis for the incidence of cancer in human populations. When clonal expansion of partially altered cells is properly accounted for, we find it unnecessary to invoke genomic instability as an early event in malignant transformation. Environmental agents that increase the rate of clonal expansion of partially altered cells are efficient carcinogens. As a...

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PMID: 14566848
DOI: 10.1002/gcc.10264

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