Article
Multistage carcinogenesis modeling and the initiation event.
Radiation oncology investigations - 1 Jan 1997
Chadwick K H, Leenhouts H P
Abstract excerpt
Carcinogenesis is generally considered to be a multistage process classified under "initiation," "promotion," and "progression," and it is therefore of interest to know how radiation might affect them. Models which are currently being used with some success to analyze a variety of data are based on the two-mutation with clonal expansion model developed by Moolgavkar and Knudson [J Natl Cancer Inst 66:1037-1052,...
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