Article
Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.
Diabetes - 1 Jan 2001
Merriman T R, Cordell H J, Eaves I A, Danoy P A, Coraddu F, Barber R, Cucca F, Broadley S, Sawcer S, Compston A, Wordsworth P, Shatford J, Laval S, Jirholt J, Holmdahl R, Theofilopoulos A N, Kono D H, Tuomilehto J, Tuomilehto-Wolf E, Buzzetti R, Marrosu M G, Undlien D E, Rønningen K S, Ionesco-Tirgoviste C, Shield J P, Pociot F, Nerup J, Jacob C O, Polychronakos C, Bain S C, Todd J A
Abstract excerpt
Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a genetic association with the major histocompatibility complex. We have previously published evidence, from 1,708 families, for linkage and association of a haplotype of three markers in the D18S487 region of chromosome...
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