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Article

OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Nov 1995

Hamzehpour M M, Pechere J C, Plesiat P, Köhler T

Abstract excerpt

Multidrug-resistant derivatives of Pseudomonas aeruginosa PAO1 were obtained after stepwise selection on tetracycline or erythromycin. Two phenotypes were generated. The tetracycline-resistant mutant (TETR) was phenotypically similar to OprM-overexpressing strains. This group displayed cross-resistance to quinolones, chloramphenicol, and all beta-lactams tested except imipenem, with no changes in the erythromycin...

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Identifiers

PMID: 8585714
DOI: 10.1128/AAC.39.11.2392
PMCID: PMC162953

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Source receipt: pubmed, retrieved 7 Sept 2026.

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