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Article

Efflux system overexpression and decreased OprD contribute to the carbapenem heterogeneity in Pseudomonas aeruginosa.

FEMS microbiology letters - 1 Feb 2008

Ikonomidis Alexandros, Tsakris Athanassios, Kantzanou Maria, Spanakis Nicholas, Maniatis Antonios N, Pournaras Spyros

Abstract excerpt

Pseudomonas aeruginosa strains exhibiting a heterogeneous mode of growth against carbapenems have been described recently. This study investigated the underlying molecular mechanisms in four genetically unrelated P. aeruginosa clinical isolates that were previously characterized by population analyses as heterogeneously resistant against carbapenems. Mutant subpopulations of all four isolates had at least...

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Identifiers

PMID: 18070070
DOI: 10.1111/j.1574-6968.2007.00997.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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