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Article

Proliferation and differentiation of a human hepatoblastoma transplanted in the Nude mouse.

Journal of hepatology - 1 Nov 1995

Desdouets C, Fabre M, Gauthier F, Bréchot C, Sobczak-Thépot J

Abstract excerpt

A pure epithelial human hepatoblastoma was directly transplanted to athymic Nude mice to provide a model system to study proliferation and differentiation of these tumoral cells. The first transplantation selected the embryonal component of this tumor, while subsequent passages selected in addition neuroendocrine and mesenchymal cells that evolved into osteoid and bony trabeculae. The embryonal character of this...

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PMID: 8583146
DOI: 10.1016/0168-8278(95)80064-6

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