In situ hybridization: application to the study of gene expression during experimental hepatocarcinogenesis and human hepatocellular carcinoma.

Abstract excerpt

The possibility of detecting specific mRNA directly within tumor cells offered by the in situ hybridization (ISH) technique has provided a new dimension to the study of experimental and human hepatocarcinogenesis. The combination of ISH and immunocytochemical techniques on the same or adjacent tissue sections provides a more complete picture of the various changes in gene expression. ISH may also detect...

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