Article
Correlation of alpha-fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression.
Molecular biology of the cell - 1 May 1998
Khamzina L, Borgeat P
Abstract excerpt
The molecular mechanism of hepatic cell growth and differentiation is ill defined. In the present study, we examined the putative role of tyrosine phosphorylation in normal rat liver development and in an in vitro model, the alpha-fetoprotein-producing (AFP+) and AFP-nonproducing (AFP-) clones of...
Topics
- Animals
- Cell Differentiation
- Cell Division
- DNA
- GTPase-Activating Proteins
- Insulin
- Insulin Receptor Substrate Proteins
- Liver
- Phenotype
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Phosphorylation
- Proteins
- Rats
- Receptor, Insulin
- Tumor Cells, Cultured
- Tyrosine
- alpha-Fetoproteins