Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies.

doi:10.1038/ejhg.2008.116

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Article

Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies.

European journal of human genetics : EJHG - 1 Dec 2008

Yang Wanling, Wang Zhanyong, Wang Lusheng, Sham Pak-Chung, Huang Peng, Lau Yu Lung

Abstract excerpt

With genotyping of high-density single nucleotide polymorphisms (SNPs) replacing that of microsatellite markers in linkage studies, it becomes possible to accurately determine the genomic regions shared identity by descent (IBD) by family members. In addition to evaluating the likelihood of linkage for a region with the underlining disease (the LOD score approach), an appropriate question to ask is what would be...

Topics

Base Sequence
Bayes Theorem
Chromosome Mapping
Computer Simulation
Family
Family Characteristics
Gene Frequency
Genes, Dominant
Genome-Wide Association Study
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inheritance Patterns

Lod Score

Pedigree

Penetrance

Polymorphism, Single Nucleotide

Quantitative Trait, Heritable

Source

Open in PubMed

Identifiers

PMID: 18575462
DOI: 10.1038/ejhg.2008.116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18575462-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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