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Article

DNA binding and dimerization of the Fe-S-containing FNR protein from Escherichia coli are regulated by oxygen.

The Journal of biological chemistry - 2 Feb 1996

Lazazzera B A, Beinert H, Khoroshilova N, Kennedy M C, Kiley P J

Abstract excerpt

The transcription factor FNR from Escherichia coli regulates transcription of genes in response to oxygen deprivation. To determine how the activity of FNR is regulated by oxygen, a form of FNR had to be isolated that had properties similar to those observed in vivo. This was accomplished by purification of an FNR fraction which exhibited enhanced DNA binding in the absence of oxygen. Iron and sulfide analyses of...

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PMID: 8576252
DOI: 10.1074/jbc.271.5.2762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA binding and dimerization of the Fe-S-containing FNR protein from Escherichia coli are regulated by oxygen.PMID 8576252Read ↗

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FNR-DNA interactions at natural and semi-synthetic promoters.Semantic proximity Read ↗

Miscoordination of the iron-sulfur clusters of the anaerobic transcription factor, FNR, allows simple repression but not activation.Semantic proximity Read ↗

Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.Semantic proximity Read ↗

The activity of the Escherichia coli transcription factor FNR is regulated by a change in oligomeric state.Semantic proximity Read ↗

In vivo and in vitro mutants of FNR the anaerobic transcriptional regulator of E. coli.Semantic proximity Read ↗

Regulation of aerobic-to-anaerobic transitions by the FNR cycle in Escherichia coli.Semantic proximity Read ↗

Transcription activation by FNR: evidence for a functional activating region 2.Semantic proximity Read ↗

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Anaerobic acquisition of [4FE 4S] clusters by the inactive FNR(C20S) variant and restoration of activity by second-site amino acid substitutions.Semantic proximity Read ↗

Covalently linking the Escherichia coli global anaerobic regulator FNR in tandem allows it to function as an oxygen stable dimer.Semantic proximity Read ↗

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