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Article

Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.

The Journal of biological chemistry - 1 Oct 2004

Chander Monica, Demple Bruce

Abstract excerpt

SoxR protein, a member of the MerR family of transcriptional activators, mediates a global oxidative stress response in Escherichia coli. Upon oxidation or nitrosylation of its [2Fe-2S] centers SoxR activates its target gene, soxS, by mediating a structural transition in the promoter DNA that stimulates initiation by RNA polymerase. We explored the molecular basis of this signal transduction by analyzing mutant...

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Share to Escherichia coli Proteins
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15292172
DOI: 10.1074/jbc.M405512200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.PMID 15292172Read ↗

Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.Semantic proximity Read ↗

Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form.Semantic proximity Read ↗

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator.Semantic proximity Read ↗

Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.Semantic proximity Read ↗

Regulation of the soxRS oxidative stress regulon. Reversible oxidation of the Fe-S centers of SoxR in vivo.Semantic proximity Read ↗

A reducing system of the superoxide sensor SoxR in Escherichia coli.Semantic proximity Read ↗

A comprehensive alanine scanning mutagenesis of the Escherichia coli transcriptional activator SoxS: identifying amino acids important for DNA binding and transcription activation.Semantic proximity Read ↗

A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator.Semantic proximity Read ↗

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Novel protein--protein interaction between Escherichia coli SoxS and the DNA binding determinant of the RNA polymerase alpha subunit: SoxS functions as a co-sigma factor and redeploys RNA polymerase from UP-element-containing promoters to SoxS-dependent promoters during oxidative stress.Semantic proximity Read ↗

Functional Characterization of RseC in the SoxR Reducing System and Its Role in Oxidative Stress Response in Escherichia coli.Semantic proximity Read ↗

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