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Article

patched overexpression causes loss of wingless expression in Drosophila embryos.

Developmental biology - 1 Jul 1994

Schuske K, Hooper J E, Scott M P

Abstract excerpt

The patched (ptc) segment polarity gene of Drosophila encodes a transmembrane protein involved in cell signaling that establishes pattern within the segment. In the posterior half of the parasegment Patched protein represses transcription of the wingless (wg) gene by an unknown mechanism. In the...

Topics

Animals
Drosophila
Drosophila Proteins
Female
Gene Expression Regulation
Insect Hormones
Membrane Proteins
Phenotype
Promoter Regions, Genetic
Proto-Oncogene Proteins
Receptors, Cell Surface
Wnt1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8026632
DOI: 10.1006/dbio.1994.1200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8026632-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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patched overexpression causes loss of wingless expression in Drosophila embryos.PMID 8026632Read ↗

Unrestricted expression of the Drosophila gene patched allows a normal segment polarity.Semantic proximity Read ↗

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets.Semantic proximity Read ↗

The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs.Semantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.Semantic proximity Read ↗

The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo.Semantic proximity Read ↗

Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos.Semantic proximity Read ↗

The patched signaling pathway mediates repression of gooseberry allowing neuroblast specification by wingless during Drosophila neurogenesis.Semantic proximity Read ↗

Differential requirements for segment polarity genes in wingless signaling.Semantic proximity Read ↗

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.Semantic proximity Read ↗

Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed.Semantic proximity Read ↗

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.Semantic proximity Read ↗

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