Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

doi:10.1128/AAC.34.6.1271

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Article

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Jun 1990

Yoshida H, Bogaki M, Nakamura M, Nakamura S

Abstract excerpt

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially i...

Topics

4-Quinolones
Anti-Infective Agents
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Escherichia coli
Mutation

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