Article
Familial dysmyelination in a Long Evans rat mutant.
Laboratory animal science - 1 Oct 1995
Delaney K H, Kwiecien J M, Wegiel J, Wisniewski H M, Percy D H, Fletch A L
Abstract excerpt
Tremors were observed in 15 Long Evans rats beginning at 10 to 12 days of age. These were followed by progressively worsening ataxia, hind limb paresis, episodes of immobility, and seizures by 5 to 14 weeks. Gross lesions were not observed at necropsy in rats euthanized and perfused at 4 to 16 we...
Topics
- Animals
- Axons
- Corpus Callosum
- Cytoplasm
- Demyelinating Diseases
- Disease Models, Animal
- Female
- Genes, Recessive
- Male
- Mutation
- Myelin Sheath
- Nerve Degeneration
- Oligodendroglia
- Pedigree
- Rats
- Rats, Mutant Strains
- Rodent Diseases
- Spinal Cord