Article
Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model.
Brain research - 15 Jan 2018
Landrock Kerstin K, Sullivan Patti, Martini-Stoica Heidi, Goldstein David S, Graham Brett H, Yamamoto Shinya, Bellen Hugo J, Gibbs Richard A, Chen Rui, D'Amelio Marcello, Stoica George
Abstract excerpt
In this study, we analyze the neuropathological and biochemical alterations involved in the pathogenesis of a neurodegenerative/movement disorder during different developmental stages in juvenile rats with a mutant Myosin5a (Myo5a). In mutant rats, a spontaneous autosomal recessive mutation characterized by the absence of Myo5a protein expression in the brain is associated with a syndrome of locomotor...
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